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Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance

21 May 2021

Abstract excerpt

Histone eviction and chromatin relaxation are important processes for efficient DNA repair. Poly(ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and disruption of PARP1 activity has a direct impact on chromatin structure. PARP inhibitors (PARPis) have been established as a treatment for BRCA1- or BRCA2-deficient tumors. Unfortunately, PARPi resistance occurs in many patients and the...

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PMID: 34030964
DOI: 10.1016/j.molmed.2021.04.010

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