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Article

Causal effect of gut-microbiota-derived metabolite trimethylamine N-oxide on Parkinson's disease: A Mendelian randomization study.

European journal of neurology - 1 Nov 2023

Zhou Hang, Luo Yuqi, Zhang Wenjie, Xie Fen, Deng Chao, Zheng Wenhua, Zhu Shuzhen, Wang Qing

Abstract excerpt

BACKGROUND AND PURPOSE: It has been suggested that trimethylamine N-oxide (TMAO) is related to Parkinson's disease (PD) in observational studies. However, the direction of this association is inconsistent. An exploratory Mendelian randomization study was conducted to investigate whether TMAO and its precursors have a causal relationship with PD. METHODS: Summary statistics were obtained for single nucleotide...

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PMID: 36692876
DOI: 10.1111/ene.15702

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