Unveiling the causal effects of phosphatidylethanolamine (18:1_0:0) via glutamine conjugate of C6H10O2 (2) and X-23648 in Parkinson's disease: insights from mediation Mendelian randomization.

Abstract excerpt

OBJECTIVE: The effects of lipidome and its metabolites on Parkinson's disease (PD) have not been fully elucidated. This study aimed to assess the causal effects of lipidome on PD and the mediated effects of metabolites using Mendelian randomization (MR). METHODS: Datasets of the lipidome, metabolites, and PD were acquired from genome-wide association studies, and single nucleotide polymorphisms were screened...

Topics

Join the communities discussing this publication.

• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Glutamine
• Mendelian Randomization Analysis
• Parkinson Disease