Article

The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in <i>Shigella flexneri</i>

2025-12-22

Abstract excerpt

In bacteria, nucleoid-structuring proteins bind and constrain DNA, often leading to transcriptional silencing. In Shigella spp ., the histone-like nucleoid-structuring protein H-NS silences many genes on the large virulence plasmid. Upon a shift to human body temperature, VirB, a DNA-binding protein and key transcriptional regulator of the Shigella virulence cascade, is produced. VirB counteracts H-NS-mediated t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b7d93be-db83-5590-9ec4-749170c2f8a9
DOI: 10.64898/2025.12.19.695565

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in <i>Shigella flexneri</i>DOI 10.64898/2025.12.19.695565Read

The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in Shigella flexneri.Semantic proximity Read

The virulence regulator VirB from <i>Shigella flexneri</i> uses a CTP-dependent switch mechanism to activate gene expressionSemantic proximity Read

The Antiactivator of Type III Secretion, OspD1, Is Transcriptionally Regulated by VirB and H-NS from Remote Sequences in Shigella flexneriSemantic proximity Read

Virulence Gene Regulation in <i>Shigella</i>Semantic proximity Read

The <i>pcnB</i> gene sustains <i>Shigella flexneri</i> virulenceSemantic proximity Read

Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature‐dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H‐NSSemantic proximity Read

The Multifaceted Activity of the VirF Regulatory Protein in the Shigella LifestyleSemantic proximity Read

Nucleoid-associated proteins shape the global protein occupancy and transcriptional landscape of a clinical isolate of <i>Vibrio cholerae</i>Semantic proximity Read

In vitro DNA-binding properties of VirB, the Shigella flexneri virulence regulatory protein.Semantic proximity Read

Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.Semantic proximity Read

Molecular mechanism of plasmid elimination by the DdmDE defense systemSemantic proximity Read

Deregulation of temperature-dependent transcription of the invasion regulatory gene, virB, in Shigella by rho mutation.Semantic proximity Read