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The virulence regulator VirB from <i>Shigella flexneri</i> uses a CTP-dependent switch mechanism to activate gene expression

2023-06-01

Abstract excerpt

The transcriptional antisilencer VirB acts as a master regulator of virulence gene expression in the human pathogen Shigella flexneri . It binds defined sequences ( virS ) upstream of VirB-dependent promoters and counteracts their silencing by the nucleoid-organizing protein H-NS. However, its precise mode of action remains unclear. Notably, VirB is not a classical transcription factor but related to DNA partiti...

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Identifiers and source

Literature Corpus work
c25d8013-6131-5dbf-a41f-7ee2e7b716f6
DOI
10.1101/2023.06.01.543266
Open publication

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