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Article

The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in Shigella flexneri.

Nucleic acids research - 24 Feb 2026

Gerson Taylor M, Karney Monika M A, Wing Helen J

Abstract excerpt

In bacteria, nucleoid-structuring proteins bind and constrain DNA, often leading to transcriptional silencing. In Shigella spp., the histone-like nucleoid-structuring protein H-NS silences many genes on the large virulence plasmid. Upon a shift to human body temperature, VirB, a DNA-binding protein and key transcriptional regulator of the Shigella virulence cascade, is produced. VirB counteracts H-NS-mediated...

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Share to Bacterial Proteins
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Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41755629
DOI: 10.1093/nar/gkag115
PMCID: PMC12956337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in Shigella flexneri.PMID 41755629Read ↗

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