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Article

Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.

Proteins - 1 Jul 2016

Xu Kehan, Dedic Emil, Brodersen Ditlev E

Abstract excerpt

The VapC toxin from the Shigella flexneri 2a virulence plasmid pMYSH6000 belongs to the PIN domain protein family, which is characterized by a conserved fold with low amino acid sequence conservation. The toxin is a bona fide Mg(2+) -dependent ribonuclease and has been shown to target initiator tRNA(fMet) in vivo. Here, we present crystal structures of active site catalytic triad mutants D7A, D7N, and D98N of the...

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PMID: 26833558
DOI: 10.1002/prot.25002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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