Article

Mitochondrial ROS drive resistance to chemotherapy and immune killing in hypoxic non-small cell lung cancer

2022-05-27

Abstract excerpt

<title>Abstract</title> <p>Background. Solid tumors subjected to intermittent hypoxia are characterized by resistance to chemotherapy and immune-killing by effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular circuitries determining this double resistance are not known. Methods. We analyzed a panel of 28 human non-small cell lung cancer (NSCLC) lines, using an <italic>in v...

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Literature Corpus work: 8b4a33fc-dc73-5794-9ab3-814060d253d0
DOI: 10.21203/rs.3.rs-1684602/v1

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