Article

HIF-1-Dependent Heme Synthesis Promotes Gemcitabine Resistance In Human Non-Small Cell Lung Cancers Via Enhanced ABCB6 Expression

2021-04-06

Abstract excerpt

<h4>Background: </h4> Gemcitabine, a deoxycytidine analogue, is commonly used in the treatment of various types of tumors, including human non-small cell lung cancer (NSCLC). However, even the initial responders rapidly develop acquired resistance which limits our ability to effectively treat advanced NSCLC. The present study reports a widely prevalent mechanism of resistance to gemcitabine in NSCLC, whereby induc...

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Literature Corpus work: fe25f698-dca6-5184-a368-b9976495e22f
DOI: 10.21203/rs.3.rs-365245/v1

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