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TFEB controls sensitivity to chemotherapy and immuno-killing in non-small cell lung cancer

7 Aug 2024

Abstract excerpt

Abstract Background In non-small cell lung cancer (NSCLC) the efficacy of chemo-immunotherapy is affected by the high expression of drug efflux transporters as ABCC1 and by the low expression of ABCA1, mediating the isopentenyl pyrophosphate (IPP)-dependent anti-tumor activation of Vγ9Vδ2 T-lymphocytes. In endothelial cells ABCA1 is a predicted target of the transcription factor EB (TFEB), but no data exists on...

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PMID: 39107857
DOI: 10.1186/s13046-024-03142-4

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