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Article

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

11 Nov 2019

Abstract excerpt

AIM: Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. METHODS:...

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PMID: 31711497
DOI: 10.1186/s12943-019-1089-9

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