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Article

Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC)

27 Aug 2009

Abstract excerpt

BACKGROUND: NSCLC exhibits considerable heterogeneity in its sensitivity to chemotherapy and similar heterogeneity is noted in vitro in a variety of model systems. This study has tested the hypothesis that the molecular basis of the observed in vitro chemosensitivity of NSCLC lies within the known resistance mechanisms inherent to these patients' tumors. METHODS: The chemosensitivity of a series of 49 NSCLC...

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PMID: 19712441
DOI: 10.1186/1471-2407-9-300

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