WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Abstract excerpt

Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart and show that this network is regulated by the E3 ubiquitin ligase WWP2, specifically by the WWP2-N terminal isoform. Importantly, the WWP2-regulated pro-fibrotic gene network is conserved...

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• Cardiac Fibrosis and Remodeling
• Peptidase Inhibition and Analysis
• Protease and Inhibitor Mechanisms