Article

Earliest observation of the tetracycline destructase <i>tet(X3)</i>

2023-08-30

Abstract excerpt

Tigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii . Plasmids harboring variants of the tetracycline destructase tet(X) promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain predating tigecycline’s commercialization, suggesting selective pressures other than tigecycline contributed to its emergence.

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b1023c2-9021-5da2-a247-986c45d0807c
DOI: 10.1101/2023.08.29.555419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Earliest observation of the tetracycline destructase <i>tet(X3)</i>DOI 10.1101/2023.08.29.555419Read

Source tracking and global distribution of the mobilized tigecycline resistant gene <i>tet</i> (X)Semantic proximity Read

Presence of Mobile Tigecycline Resistance Gene <i>tet</i> (X4) in Clinical Klebsiella pneumoniaeSemantic proximity Read

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline ResistanceSemantic proximity Read

Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.Semantic proximity Read

Preliminary view of the global distribution and spread of the tet(X) family of tigecycline resistance genesSemantic proximity Read

Global dissemination of tet(X3) and tet(X6) among livestock-associated Acinetobacter is sporadic and mediated by highly diverse plasmidomesSemantic proximity Read

Phenotypic and genomic analysis reveals Riemerella anatipestifer as the potential reservoir of tet(X) variantsSemantic proximity Read

Comparison of <i>tet</i> (X4)-containing contigs from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjectsSemantic proximity Read

Global prevalence, characteristics, and future prospects of IncX3 plasmids: A reviewSemantic proximity Read

A transferable IncC-IncX3 hybrid plasmid co-carrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X4), and <i>tmexCD3-toprJ3</i> confers resistance to carbapenem and tigecyclineSemantic proximity Read

Mechanistic Insights into Crosstalk of Tet(X) and MCR-1, Two Resistance Enzymes Co-produced by A Single PlasmidSemantic proximity Read

Co‐production of Tet(X) and MCR ‐1, two resistance enzymes by a single plasmidSemantic proximity Read