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A transferable IncC-IncX3 hybrid plasmid co-carrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X4), and <i>tmexCD3-toprJ3</i> confers resistance to carbapenem and tigecycline

2021-07-01

Abstract excerpt

Tigecycline is a last-resort antimicrobial that exhibits promising activity against carbapenemase-producing Enterobacterales (CPE). However, mobile tigecycline resistance genes, tet (X) and tmexCD-toprJ , have emerged in China and have spread possibly worldwide. Tet(X) family proteins, Tet(X3) to Tet(X14), function as tigecycline-inactivating enzymes, and TMexCD-TOprJ complexes function as efflux pumps for tigec...

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Literature Corpus work
be9041cb-9b1f-5636-924e-a8dc23060f1d
DOI
10.1101/2021.06.30.450641
Open publication

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A transferable IncC-IncX3 hybrid plasmid co-carrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X4), and <i>tmexCD3-toprJ3</i> confers resistance to carbapenem and tigecyclineDOI 10.1101/2021.06.30.450641
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