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Article

The expanding tet(X) gene family: Public health risks from cross-species transmission revealed by genomic big data mining.

Journal of global antimicrobial resistance - 1 Sept 2026

Zhang Tingting, Han Na, Peng Xianhui, Qiang Yujun, Li Xiuwen, Zhang Wen

Abstract excerpt

OBJECTIVES: To investigate the tet(X) gene family, which confers resistance to all tetracycline antibiotics, in terms of diversity, dissemination dynamics and evolutionary risks. METHODS: We conducted a large-scale genomic data mining of 2 299 771 bacterial genomes. Tet(X) homologs were identified using BLAT. Phylogenetic analysis, plasmid identification and epidemiological statistics were employed to elucidate...

Read the complete abstract on PubMed

Topics

Phylogeny
Humans
Genome, Bacterial
Data Mining
Genomics
Plasmids
Big Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Public Health

Gene Transfer, Horizontal

Anti-Bacterial Agents

Tetracycline Resistance

Vibrio cholerae

Bacteria

Polymorphism, Single Nucleotide

Bacterial Proteins

Source

Identifiers

PMID: 42336203
DOI: 10.1016/j.jgar.2026.06.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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