Article

Source tracking and global distribution of the mobilized tigecycline resistant gene <i>tet</i> (X)

2021-08-01

Abstract excerpt

The emergence of tet (X) genes has compromised the clinical use of the last-line antibiotic tigecycline. We identified 322 (1.21%) tet (X) positive samples from 12,829 human microbiome samples distributed in four continents (Asia, Europe, North America and South America) using retrospective data from worldwide. These tet (X) genes were dominated by tet (X2)-like orthologs but we also identified 12 samples carr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 710a0f56-87ae-57ea-b028-cdd99a3d9c4f
DOI: 10.1101/2021.07.29.454411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Source tracking and global distribution of the mobilized tigecycline resistant gene <i>tet</i> (X)DOI 10.1101/2021.07.29.454411Read

Preliminary view of the global distribution and spread of the tet(X) family of tigecycline resistance genesSemantic proximity Read

Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.Semantic proximity Read

Comparison of <i>tet</i> (X4)-containing contigs from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjectsSemantic proximity Read

Phenotypic and genomic analysis reveals Riemerella anatipestifer as the potential reservoir of tet(X) variantsSemantic proximity Read

Presence of Mobile Tigecycline Resistance Gene <i>tet</i> (X4) in Clinical Klebsiella pneumoniaeSemantic proximity Read

Global dissemination of tet(X3) and tet(X6) among livestock-associated Acinetobacter is sporadic and mediated by highly diverse plasmidomesSemantic proximity Read

Co-Occurrence of tet(X4) and bla NDM-5 in Escherichia coli Isolates of Inpatient Origin in Guangzhou, ChinaSemantic proximity Read

Earliest observation of the tetracycline destructase <i>tet(X3)</i>Semantic proximity Read

Functional and evolutionary insights into the emerging <i>tet</i> (X4)-carrying non-O1/O139 <i>Vibrio cholerae</i> from retail porkSemantic proximity Read

Fecal Carriage of Escherichia coli Harboring the tet(X4)-IncX1 Plasmid from a Tertiary Class-A Hospital in Beijing, ChinaSemantic proximity Read

A transferable IncC-IncX3 hybrid plasmid co-carrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X4), and <i>tmexCD3-toprJ3</i> confers resistance to carbapenem and tigecyclineSemantic proximity Read

Low prevalence of mobilized resistance genes blaNDM, mcr-1, and tet(X4) in Escherichia coli from a hospital in ChinaSemantic proximity Read