Article

Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone

2025-03-19

Abstract excerpt

Bone metastasis is becoming increasingly common globally. In such cases, cancer cells disseminate from the primary site to bone, subsequently entering a dormant state. Following a certain incubation period, the cells reawaken and grow, forming a metastatic mass. These dormant cells are called metastasis-initiating cells (MICs), but their survival and reawakening are poorly understood. Here, we established an in v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ad626d3-9338-52ba-adac-519036078802
DOI: 10.1101/2025.03.18.643632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in boneDOI 10.1101/2025.03.18.643632Read

TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinomasSemantic proximity Read

Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasisSemantic proximity Read

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosisSemantic proximity Read

Major roles of the circadian clock in cancerSemantic proximity Read

Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinaseSemantic proximity Read

Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis.Semantic proximity Read

Genetic and epigenetic associations of circadian gene TIMELESS and breast cancer risk.Semantic proximity Read

Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9Semantic proximity Read

TIMELESS as a Prognostic Biomarker and Therapeutic Target in Gastric CancerSemantic proximity Read

ncRNAs-mediated TIMELESS overexpression in lung adenocarcinoma correlates with reduced tumor immune cell infiltration and poor prognosisSemantic proximity Read

A Mesenchymal-like Program of Dormancy controlled by ZFP281 Serves as a Barrier To Metastatic Progression of Early Disseminated Cancer CellsSemantic proximity Read

TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulationSemantic proximity Read