Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

16 Feb 2023

Abstract excerpt

During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which contributes to senile osteoporosis. Previous studies have confirmed that interrupted circadian rhythm plays an indispensable role in age-related disease. However, the mechanism underlying the impaired osteogenic differentiation of BM-MSCs during aging and its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36910712
DOI: 10.1016/j.omtn.2023.02.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosisPMID 36910712Read ↗

Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axisSemantic proximity Read ↗

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integritySemantic proximity Read ↗

Circadian rhythm protein Bmal1 modulates cartilage gene expression in temporomandibular joint osteoarthritis via the MAPK/ERK pathwaySemantic proximity Read ↗

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseasesSemantic proximity Read ↗

The circadian clock gene Bmal1: Role in COVID-19 and periodontitisSemantic proximity Read ↗

Modeling the Clockwork of Bone: A Narrative Review of Experimental Approaches to Circadian Rhythm in Bone MetabolismSemantic proximity Read ↗

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathwaySemantic proximity Read ↗

Circadian Regulation of Bone RemodelingSemantic proximity Read ↗

Major roles of the circadian clock in cancerSemantic proximity Read ↗

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.Semantic proximity Read ↗

BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3Semantic proximity Read ↗

Clock gene Bmal1 influences the cell cycle of chondrocytes in osteoarthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.