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Article

Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9

10 May 2021

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a common tumor characterized by its high mortality. However, the underlying molecular mechanisms that drive CRC tumorigenesis are unclear. Clock genes have important roles in tumor development. In the present study, the expression and functions of clock gene TIMELESS (encoding the Timeless protein) in CRC were investigated. METHODS: Immunohistochemistry, cell proliferation,...

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PMID: 33971927
DOI: 10.1186/s13046-021-01936-4

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