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Article

The role of the DNA damage response pathways in brain development and microcephaly: insight from human disorders.

DNA repair - 1 Jul 2008

O'Driscoll Mark, Jeggo Penny A

Abstract excerpt

A network of DNA damage response (DDR) mechanisms functions co-ordinately to maintain genomic stability and ensure cellular survival in the face of exogenous and endogenous DNA damage. Defects in DDR pathways have been identified in a range of human disorders, collectively classified as DDR-defective syndromes. A common feature of these syndromes is a predisposition to cancer demonstrating the importance of the...

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Identifiers

PMID: 18458003
DOI: 10.1016/j.dnarep.2008.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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