Article

Circular RNA-Encoded MET Variant Is a Targetable Factor in Glioblastoma

2022-06-28

Abstract excerpt

<title>Abstract</title> <p>Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma stem cell (GSC) self-renewal, invasiveness and tumorigenicity. Nevertheless, HGF/MET-targeted therapy has shown limited clinical benefits in glioblastoma patients, suggesting hidden mechanisms of MET signalling in glioblastoma. Here, we show that circular...

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Literature Corpus work: 8aca7140-eba9-5575-85ed-38bcc8b09713
DOI: 10.21203/rs.3.rs-1730428/v1

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