Article

Extensive MET alterations confer clinical response to MET inhibitors in gliomas

2020-11-02

Abstract excerpt

Activating alterations of the MET gene are well-characterized oncogenic drivers, and MET inhibitors could successfully treat several tumor types with MET alterations, including gliomas with PTPRZ1-MET fusion. However, the full diversity and prevalence of MET alterations in gliomas are still lacking to accurately identify a subset of patients likely to benefit from MET inhibitor treatment. Here, we interrogated gen...

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Literature Corpus work: 759d38f1-b82d-5a8d-9763-74c51ae7535b
DOI: 10.1101/2020.11.02.364711

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