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Article

Circular RNA encoded MET variant promotes glioblastoma tumorigenesis

25 Jul 2023

Abstract excerpt

Abstract Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and tumorigenicity. Nevertheless, HGF/MET-targeted therapy has shown limited clinical benefits in GBM patients, suggesting hidden mechanisms of MET signalling in GBM. Here, we show that circular MET RNA (circMET) encodes a...

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PMID: 37491377
DOI: 10.1038/s41467-023-40212-1

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