Article

ERRα/VDR Axis Promotes Calcitriol Degradation and Estrogen Signaling Activation and Correlates with Poor Prognosis in Basal-like Breast Cancer Patients.

2020-08-17

Abstract excerpt

<h4>Background: </h4> Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the VDR pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol. Besides ERα, another nuclear receptor, ERRα, has recently been shown to interfere with the VDR pathway, but its role in the cytotoxicity and transactivation activity of calcitriol is completely unkno...

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Literature Corpus work: 8aba338e-730b-52ac-bd4f-3b402b2a30f2
DOI: 10.21203/rs.3.rs-58830/v1

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