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Article

Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer

1 Mar 2013

Abstract excerpt

Cells must continuously respond to stressful insults via the upregulation of cytoprotective pathways. The longevity factor and deacetylase SIRT1 plays a critical role in coordinating this cellular response to stress. SIRT1 activity and levels are regulated by cellular stressors, including metabolic, genotoxic, oxidative, and proteotoxic stress. As a stress sensor, SIRT1 impacts cell survival by deacetylating...

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PMID: 24020008
DOI: 10.1177/1947601913484497

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