SIRT2 regulates oxidative stress response in liver fibrosis mice through the NLRP3 inflammasome pathway

Abstract excerpt

<title>Abstract</title> <p>Liver fibrosis is a crucial step in the progression of various chronic liver diseases to cirrhosis, which can affect the prognosis of chronic liver diseases. The NAD⁺ dependent deacetylase sirtuins family member SIRT2 can regulate the inflammatory corpuscular pathway in pathological processes, but its related mechanism is not yet clear. This study established liver fibrosis m...

Topics

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• Acetylation
• Biochemical effects in animals
• Curcumin's Biomedical Applications
• Endoplasmic Reticulum Stress and Disease
• Gene Knockdown Techniques
• Genomics, phytochemicals, and oxidative stress
• Liver Disease Diagnosis and Treatment
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

50c6258e-060f-52a6-9803-cb8c92ecdf31

DOI

10.21203/rs.3.rs-3331618/v1