Article

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002-09-01

Abstract excerpt

Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation of the cdk-inhibitor p27 and is a bona fide proto-oncoprotein. Using microarray analysis and immunohistochemistry, we determined that higher levels of Skp2 are present more frequently in E...

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Literature Corpus work: 8a8af636-2e24-5ffb-92c8-af5ba6bb9fe3
DOI: 10.1172/jci0215795

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