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The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

19 Jul 2005

Abstract excerpt

INTRODUCTION: Loss of the cell-cycle inhibitory protein p27Kip1 is associated with a poor prognosis in breast cancer. The decrease in the levels of this protein is the result of increased proteasome-dependent degradation, mediated and rate-limited by its specific ubiquitin ligase subunits S-phase kinase protein 2 (Skp2) and cyclin-dependent kinase subunit 1 (Cks1). Skp2 was recently found to be overexpressed in...

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PMID: 16168119
DOI: 10.1186/bcr1278

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