Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype.

Human pathology - 1 Oct 2008

Voduc David, Nielsen Torsten O, Cheang Maggie C, Foulkes William D

Abstract excerpt

Gene expression studies have identified a basal phenotype of breast cancer; these are hormone receptor and HER2-negative cancers with poor prognosis. High levels of cyclin E and Skp2, and low levels of p27 have previously been individually associated with both basal-like breast cancer and a poor outcome after diagnosis. The goal of this study was to first confirm the prognostic value of these biomolecular markers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Cyclin E
Share to Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Proliferating Cell Nuclear Antigen

Share to S-Phase Kinase-Associated Proteins

Share to Survival Rate

Share to Tissue Array Analysis

Source

Identifiers

PMID: 18620730
DOI: 10.1016/j.humpath.2008.03.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype.PMID 18620730Read ↗

Cyclin E expression in breast cancer: predicting germline BRCA1 mutations, prognosis and response to treatmentSemantic proximity Read ↗

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.Semantic proximity Read ↗

Cyclin E1 and cyclin E2 in ER+ breast cancer: prospects as biomarkers and therapeutic targetsSemantic proximity Read ↗

E- and A-type cyclins as markers for cancer diagnosis and prognosisSemantic proximity Read ↗

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patientsSemantic proximity Read ↗

The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer.Semantic proximity Read ↗

Prognostic value of basal phenotype in HER2-overexpressing breast cancer.Semantic proximity Read ↗

Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers.Semantic proximity Read ↗

Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes.Semantic proximity Read ↗

[Basal-like breast cancer: a review].Semantic proximity Read ↗

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancerSemantic proximity Read ↗

Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.