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Article

Skp2 Inhibitors: Novel Anticancer Strategies

11 May 2016

Abstract excerpt

Skp2 is frequently overexpressed in many human cancers and plays a key role in tumorigenesis. As a component of the SCFSkp2ubiquitin E3 ligase complex, Skp2 is responsible for recruiting substrate proteins for their ubiquitination and subsequent degradation by the 26S proteasome. Thus, Skp2 promotes the cell cycle by down-regulating cell cycle proteins such as the tumor suppressor p27. Alternatively, Skp2...

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PMID: 27160538
DOI: 10.2174/0929867323666160510122624

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