Article

Manipulating base quality scores enables variant calling from bisulfite sequencing alignments using conventional Bayesian approaches

2021-01-11

Abstract excerpt

Calling germline SNP variants from bisulfite-converted sequencing data poses a challenge for conventional software, which have no inherent capability to dissociate true polymorphisms from artificial mutations induced by the chemical treatment. Nevertheless, SNP data is desirable both for genotyping and to understand the DNA methylome in the context of the genetic background. The confounding effect of bisulfite con...

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Literature Corpus work: 8a8a59b2-61bd-5db5-bd2b-f563ac030ef3
DOI: 10.1101/2021.01.11.425926

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