Article
SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia.
Respiratory investigation - 1 Jan 2023
Fishchuk Liliia, Rossokha Zoia, Pokhylko Valeriy, Cherniavska Yuliia, Popova Olena, Vershyhora Viktoriia, Kovtun Serhii, Gorovenko Nataliia
Abstract excerpt
BACKGROUND: Exploring the pathogenetic mechanisms behind severe lung damage in COVID-19 is crucial. In this study, we decided to focus on two molecular markers that affect surfactant metabolism and lung development: the surfactant protein B (SFTPB) and the glucocorticoid receptor (NR3C1) genes. The aim of our study was to determine the effect of SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants on the...
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