Article

The TLR-2/TonEBP Signaling Pathway Regulates 29-kDa Fibronectin Fragment-dependent Expression of Matrix Metalloproteinases

2021-01-21

Abstract excerpt

Tonicity-responsive enhancer-binding protein (TonEBP; nuclear factor of activated T cells 5) is a transcription factor that responds to changes in osmolality. However, recent studies have shown that it also modulates immune responses under inflammatory conditions independently of hyperosmolality. Fibronectin fragments (FN-fs), which are abundant in the synovial fluid of patients with osteoarthritis (OA), induce ex...

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Literature Corpus work: 8a3a7a0c-a45e-507c-97dd-6cc3fa5ce818
DOI: 10.21203/rs.3.rs-148101/v1

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