Article
Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases.
Pathology international - 1 May 2011
Uede Toshimitsu
Abstract excerpt
Within classical extracellular matrix (ECM) proteins, there are a unique group of proteins that should be regarded as a distinct functional group of molecules. Matricellular proteins including osteopontin (OPN) and tenascin-c (TN-C) are highly expressed at the pathological foci of various inflammatory diseases. Unlike classical ECM proteins, these are soluble proteins and induce cell motility and persistent...
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