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Complement receptor-mediated uptake into renal mononuclear phagocytes promotes intracellular UPEC persistence and limits β-lactam efficacy in pyelonephritis

2026-07-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Acute pyelonephritis remains a major clinical problem. Relapses occur despite apparently appropriate antibiotic therapy, suggesting that uropathogenic Escherichia coli (UPEC) persist in intrarenal niches. Intracellular bacterial reservoirs are a plausible explanation, but the relevant host cells, entry mechanisms and therapeutic implications in the kidney remain undefined....

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Literature Corpus work
8a163010-709c-5c8b-abd4-25655437e650
DOI
10.64898/2026.07.09.737431
Open publication

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Complement receptor-mediated uptake into renal mononuclear phagocytes promotes intracellular UPEC persistence and limits β-lactam efficacy in pyelonephritisDOI 10.64898/2026.07.09.737431
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