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Early Terminal Complement Blockade and C6 Deficiency Are Protective in Enterohemorrhagic Escherichia coli –Infected Mice

15 Jul 2016

Abstract excerpt

Complement activation occurs during enterohemorrhagic Escherichia coli (EHEC) infection and may exacerbate renal manifestations. In this study, we show glomerular C5b-9 deposits in the renal biopsy of a child with EHEC-associated hemolytic uremic syndrome. The role of the terminal complement complex, and its blockade as a therapeutic modality, was investigated in a mouse model of E. coli O157:H7 infection. BALB/c...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27421478
DOI: 10.4049/jimmunol.1502377

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