Article
Phenotypic heterogeneity enables uropathogenic Escherichia coli to evade killing by antibiotics and serum complement.
Infection and immunity - 1 Mar 2015
Putrinš Marta, Kogermann Karin, Lukk Eliisa, Lippus Markus, Varik Vallo, Tenson Tanel
Abstract excerpt
Uropathogenic strains of Escherichia coli (UPEC) are the major cause of bacteremic urinary tract infections. Survival in the bloodstream is associated with different mechanisms that help to resist serum complement-mediated killing. While the phenotypic heterogeneity of bacteria has been shown to influence antibiotic tolerance, the possibility that it makes cells refractory to killing by the immune system has not...
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