Article
The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Immunity - 17 Apr 2014
Jaillon Sébastien, Moalli Federica, Ragnarsdottir Bryndis, Bonavita Eduardo, Puthia Manoj, Riva Federica, Barbati Elisa, Nebuloni Manuela, Cvetko Krajinovic Lidija, Markotic Alemka, Valentino Sonia, Doni Andrea, Tartari Silvia, Graziani Giorgio, Montanelli Alessandro, Delneste Yves, Svanborg Catharina, Garlanda Cecilia, Mantovani Alberto
Abstract excerpt
Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.