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Article

Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection.

PLoS pathogens - 12 Aug 2010

Hannan Thomas J, Mysorekar Indira U, Hung Chia S, Isaacson-Schmid Megan L, Hultgren Scott J

Abstract excerpt

Chronic infections are an increasing problem due to the aging population and the increase in antibiotic resistant organisms. Therefore, understanding the host-pathogen interactions that result in chronic infection is of great importance. Here, we investigate the molecular basis of chronic bacterial cystitis. We establish that introduction of uropathogenic E. coli (UPEC) into the bladders of C3H mice results in...

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Source

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Identifiers

PMID: 20811584
DOI: 10.1371/journal.ppat.1001042
PMCID: PMC2930321

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection.PMID 20811584Read ↗

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