Metformin Does Not Significantly Alter Longitudinal Dynamics of Clonal Hematopoiesis.

doi:10.1158/1078-0432.CCR-25-3606

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Article

Metformin Does Not Significantly Alter Longitudinal Dynamics of Clonal Hematopoiesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2026

Pareek Eshani, Pershad Yash, Zhao Kun, Uddin Md Mesbah, Xue Liying, Vlasschaert Caitlyn, Mack Taralynn M, Haessler Jeffrey, Collins Jason M, Glick Elena, Glaser Veronica, Heise Rachel, Ling Wodan, Haring Bernhard, Shadyab Aladdin, Beydoun Hind, Wallace Robert, Jaiswal Siddhartha, Manson JoAnn E, Natarajan Pradeep, Honigberg Michael C, Kooperberg Charles, Whitsel Eric A, Kitzman Jacob O, Bick Alexander G, Reiner Alexander P, Desai Pinkal

Abstract excerpt

PURPOSE: Early intervention in patients with clonal hematopoiesis (CH) is an area of intense investigation with no currently approved agents. With recent mechanistic data on metformin as a possible therapeutic agent in CH and its availability in clinical practice, we sought to investigate the clonal dynamics of CH mutations in metformin users. EXPERIMENTAL DESIGN: We analyzed longitudinal targeted deep sequencing...

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PMID: 41603726
DOI: 10.1158/1078-0432.CCR-25-3606

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DNMT3A

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