Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs.

doi:10.1038/s41586-025-08871-w

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Article

Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs.

Nature - 1 Jun 2025

Hosseini Mohsen, Voisin Veronique, Chegini Ali, Varesi Angelica, Cathelin Severine, Ayyathan Dhanoop Manikoth, Liu Alex C H, Yang Yitong, Wang Vivian, Maher Abdula, Grignano Eric, Reisz Julie A, D'Alessandro Angelo, Young Kira, Wu Yiyan, Fiumara Martina, Ferrari Samuele, Naldini Luigi, Gaiti Federico, Pai Shraddha, Egan Grace, Schimmer Aaron D, Bader Gary D, Dick John E, Xie Stephanie Z, Trowbridge Jennifer J, Chan Steven M

Abstract excerpt

Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses1-4. Suppressing the expansion of mutant HSCs may prevent these outcomes; however, such...

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PMID: 40240595
DOI: 10.1038/s41586-025-08871-w
PMCID: PMC12869297

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DNMT3A

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Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs.PMID 40240595Read ↗

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