Article
A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.
EBioMedicine - 1 May 2018
Zhou Xuezhong, Lei Lei, Liu Jun, Halu Arda, Zhang Yingying, Li Bing, Guo Zhili, Liu Guangming, Sun Changkai, Loscalzo Joseph, Sharma Amitabh, Wang Zhong
Abstract excerpt
The International Classification of Diseases (ICD) relies on clinical features and lags behind the current understanding of the molecular specificity of disease pathobiology, necessitating approaches that incorporate growing biomedical data for classifying diseases to meet the needs of precision medicine. Our analysis revealed that the heterogeneous molecular diversity of disease chapters and the blurred boundary...
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