Article
The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.
Nature computational science - 1 May 2023
Jia Gengjie, Li Yu, Zhong Xue, Wang Kanix, Pividori Milton, Alomairy Rabab, Esposito Aniello, Ltaief Hatem, Terao Chikashi, Akiyama Masato, Matsuda Koichi, Keyes David E, Im Hae Kyung, Gojobori Takashi, Kamatani Yoichiro, Kubo Michiaki, Cox Nancy J, Evans James, Gao Xin, Rzhetsky Andrey
Abstract excerpt
Human diseases are traditionally studied as singular, independent entities, limiting researchers' capacity to view human illnesses as dependent states in a complex, homeostatic system. Here, using time-stamped clinical records of over 151 million unique Americans, we construct a disease representation as points in a continuous, high-dimensional space, where diseases with similar etiology and manifestations lie...
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