Article

A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity

2019-01-21

Abstract excerpt

Small genetically-determined differences in transcription (eQTLs) are implicated in complex disease but the mechanisms by which small changes in gene expression impact complex disease are unknown. Here we show that a persistent small increase in expression of the innate sensor NOD1 precipitates large cancer-promoting changes in cell state. A ~1.2-1.4 fold increase in NOD1 protein concentration by loss of miR-15b/1...

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Literature Corpus work: 8a02b0e0-ca50-56c0-a63e-ed81b4bc7e68
DOI: 10.1101/518886

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