Article

A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity

2019-01-21

Abstract excerpt

Small genetically-determined differences in transcription (eQTLs) are implicated in complex disease but the mechanisms by which small changes in gene expression impact complex disease are unknown. Here we show that a persistent small increase in expression of the innate sensor NOD1 precipitates large cancer-promoting changes in cell state. A ~1.2-1.4 fold increase in NOD1 protein concentration by loss of miR-15b/1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a02b0e0-ca50-56c0-a63e-ed81b4bc7e68
DOI: 10.1101/518886

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 10 closest

A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activityDOI 10.1101/518886Read

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.Semantic proximity Read

Signalling pathways and molecular interactions of NOD1 and NOD2Semantic proximity Read

Quantitative adaptor heterogeneity sets single-cell thresholds for innate immune activation and attenuationSemantic proximity Read

Universal attenuators and their interactions with feedback loops in gene regulatory networksSemantic proximity Read

A bistable circuit regulates miRNA-155 levels in human macrophage inflammatory transitionsSemantic proximity Read

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancerSemantic proximity Read

Loss-of-function mutations ensure that response to immune checkpoint therapy is NOD2 be denied.Semantic proximity Read

A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.Semantic proximity Read

Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal StrengthSemantic proximity Read

Butyrate modulates the epigenetic landscape of human natural killer cells and affects their regulatory functionSemantic proximity Read