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Article

Loss-of-function mutations ensure that response to immune checkpoint therapy is NOD2 be denied.

Science immunology - 5 Sept 2025

Anderson Ana C, Rangachari Manu

Abstract excerpt

Loss-of-function mutations in NOD2 may predict positive response to PD-1 blockade monotherapy in cancer.

Read the complete abstract on PubMed

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Share to NOD2 gene
Share to Immune Checkpoint Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40911695
DOI: 10.1126/sciimmunol.aeb8333

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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A regulatory interface on RIPK2 is required for XIAP binding and NOD signaling activitySemantic proximity Read ↗

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Overcoming Genetically Based Resistance Mechanisms to PD-1 BlockadeSemantic proximity Read ↗

P03-012 - A P268S NOD2 mutation in one Blau patientSemantic proximity Read ↗

A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activitySemantic proximity Read ↗

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Structural localization of pathogenic mutations in the central nucleotide-binding domain (NBD) of nucleotide-binding oligomerization domain-2 (NOD2) protein and their inference in inflammatory disorders.Semantic proximity Read ↗

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