Article

Universal attenuators and their interactions with feedback loops in gene regulatory networks

2016-09-12

Abstract excerpt

Using a combination of mathematical modelling, statistical simulation and large-scale data analysis we study the properties of linear regulatory chains (LRCs) within gene regulatory networks (GRNs). Our modelling indicates that downstream genes embedded within LRCs are highly insulated from the variation in expression of upstream genes, and thus LRCs act as attenuators. This observation implies a progressively wea...

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Literature Corpus work: f8f7340f-1c2c-5a2c-9d51-d0ec021a5cf9
DOI: 10.1101/074716

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