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Article

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

23 May 2019

Abstract excerpt

Mammalian spermatogenesis is sustained by mitotic germ cells with self-renewal potential known as undifferentiated spermatogonia. Maintenance of undifferentiated spermatogonia and spermatogenesis is dependent on tightly co-ordinated transcriptional and post-transcriptional mechanisms. The RNA helicase DDX5 is expressed by spermatogonia but roles in spermatogenesis are unexplored. Using an inducible knockout mouse...

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PMID: 31123254
DOI: 10.1038/s41467-019-09972-7

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