Article

The RNA helicase DDX53 (CAGE) contributes to RNA metabolism in a human germ cell model

2026-02-03

Abstract excerpt

DDX53 (DEAD-box helicase 53, known also as CAGE) is an intronless gene on the X chromosome, which expression shows strong testis specificity. It belongs to the group of cancer-testis (CT) antigens, with most studies to date focusing on its role in cancer, but the precise biological function of DDX53 remains unclear. Previous reports identifying rare DDX53 variants in infertile men provided the rationale for inves...

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Literature Corpus work: 77daaddf-7137-52cd-8dc9-d3dfe5ef3499
DOI: 10.64898/2026.02.03.703580

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