Article
Genetic QT score as a predictor of sudden cardiac death in participants with sleep-disordered breathing in the UK Biobank.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine - 1 Mar 2025
Arora Amit, Zareba Wojciech, Woosley Raymond L, Klimentidis Yann C, Patel Imran Y, Quan Stuart F, Wendel Christopher, Shamoun Fadi, Guerra Stefano, Parthasarathy Sairam, Patel Salma I
Abstract excerpt
STUDY OBJECTIVES: The goal of this study was to evaluate the association between a polygenic risk score (PRS) for QT prolongation (QTc-PRS), corrected QT intervals (QTc) and sudden cardiac death (SCD) in participants enrolled in the UK Biobank with and without sleep-disordered breathing (SDB). METHODS: The QTc-PRS was calculated using allele copy number and previously reported effect estimates for each single...
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